Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 8/20 | 0.43 |
| ▸ | FAAH | O00519 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996476 | 0.80 | KMT2A (0.47) | CASP1FAAHKMT2AGLAERN1 | |
| SCHEMBL4589632 | 0.78 | KMT2A (0.54) | CASP1FAAHKMT2AGLAERN1 | |
| SCHEMBL6992696 | 0.75 | CNR1 (0.45) | CASP1FAAHKMT2AGLAERN1 | |
| SCHEMBL12201807 | 0.74 | ESRRG (0.53) | CASP1FAAHKMT2AGLA | |
| SCHEMBL14896376 | 0.73 | MAPT (0.51) | KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4590122 | 0.73 | KMT2A (0.59) | FAAHKMT2AGLAMAPT | |
| SCHEMBL9507749 | 0.72 | CASP1 (0.51) | CASP1FAAHKMT2AGLA | |
| SCHEMBL7823450 | 0.72 | MAPT (0.38) | CASP1FAAHKMT2AERN1MEN1 | |
| SCHEMBL4590421 | 0.71 | ALDH1A1 (0.55) | KMT2AGLAMEN1ALDH1A1 | |
| SCHEMBL6999007 | 0.71 | CASP1 (0.46) | CASP1FAAHKMT2AERN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027352-A4 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2001-09-19 | — | — | EP | disclosed |
| EP-1027352-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999020627-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1999-04-29 | — | — | WO | disclosed |