Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 15/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811102 | 0.91 | ALOX5 (0.58) | ALOX5LMNATSHROPRM1 | |
| SCHEMBL7810991 | 0.90 | ALOX5 (0.57) | ALOX5LMNATSHROPRM1 | |
| SCHEMBL7802551 | 0.87 | ALOX5 (0.56) | ALOX5 | |
| SCHEMBL9136129 | 0.87 | ALOX5 (0.55) | ALOX5OPRM1 | |
| SCHEMBL7810873 | 0.86 | ALOX5 (0.67) | ALOX5ALDH1A1LMNATSHRCYP2C19 | |
| SCHEMBL7811953 | 0.85 | ALOX5 (0.66) | ALOX5 | |
| SCHEMBL7815037 | 0.83 | ALOX5 (1.00) | ALOX5 | |
| SCHEMBL1600273 | 0.80 | ALOX5 (0.55) | ALOX5ALDH1A1LMNATSHRCYP2C19 | |
| SCHEMBL8551875 | 0.80 | ALOX5 (0.59) | ALOX5 | |
| SCHEMBL12707332 | 0.79 | ALOX5 (0.52) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787127-B1 | 5-LIPOXYGENASE INHIBITORS | PFIZER (US) | 2001-01-03 | — | — | EP | disclosed |
| US-6063928-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, CARDIOTONIC AGENTS | PFIZER INC (US) | 2000-05-16 | — | — | US | disclosed |
| US-5883106-A | 5-lipoxygenase inhibitors | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0787127-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996011911-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | disclosed |