Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7808973 | 0.87 | ALOX5 (0.70) | ALOX5OPRM1 | |
| SCHEMBL9136244 | 0.84 | ALOX5 (0.42) | ALOX5OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL7811102 | 0.83 | ALOX5 (0.58) | ALOX5ADAM17OPRM1OPRD1OPRK1 | |
| SCHEMBL7810991 | 0.83 | ALOX5 (0.57) | ALOX5ADAM17OPRM1OPRD1OPRK1 | |
| SCHEMBL9212748 | 0.81 | ALOX5 (0.49) | ALOX5 | |
| SCHEMBL9212541 | 0.81 | ALOX5 (0.49) | ALOX5 | |
| SCHEMBL9212534 | 0.81 | ALOX5 (0.49) | ALOX5 | |
| SCHEMBL9228704 | 0.80 | ALOX5 (0.51) | ALOX5 | |
| SCHEMBL9221969 | 0.80 | ALOX5 (0.51) | ALOX5 | |
| SCHEMBL9137545 | 0.79 | ALOX5 (0.55) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462830-B1 | Cyclic ether derivatives | ZENECA LTD (GB) | 1995-10-18 | — | — | EP | disclosed |
| US-5407945-A | Pyran derivatives and their use as inhibitors of 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES, INC. (GB) | 1995-04-18 | — | — | US | disclosed |
| US-5254581-A | Used in the treatment of various inflammatory and allergic diseases | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0462830-A2 | Cyclic ether derivatives | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |