Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8012475 | 0.85 | GAA (0.56) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL3009938 | 0.85 | GPR35 (0.53) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL3034692 | 0.85 | TSHR (0.53) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL3009943 | 0.83 | TSHR (0.51) | GPR35ALDH1A1TP53HPGDTSHR | |
| Water SCHEMBL3012136 | 0.83 | GPR35 (0.51) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL19742607 | 0.83 | GAA (0.54) | GPR35ALDH1A1TP53HPGDTSHR | |
| Water SCHEMBL3012137 | 0.82 | TSHR (0.50) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL28013151 | 0.81 | GPR35 (0.53) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL131912 | 0.81 | GPR35 (0.56) | GPR35ALDH1A1TP53HPGDTSHR | |
| SCHEMBL51277 | 0.80 | GPR35 (0.60) | GPR35ALDH1A1TP53HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117689-A1 | BONE MORPHOGENETIC PROTEIN ANTAGONISTS BASED ON THE MATURE PROTEIN | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000021998-A1 | BONE MORPHOGENETIC PROTEIN ANTAGONIST BASED ON THE MATURE PROTEIN | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH (DE) | 2000-04-20 | — | — | WO | disclosed |