Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807554 | 0.91 | ALOX5 (0.83) | ALOX5HDAC1HDAC6ALDH1A1LMNA | |
| SCHEMBL7807582 | 0.85 | ALOX5 (0.74) | ALOX5OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL7814848 | 0.83 | ALOX5 (1.00) | ALOX5OPRM1OPRD1OPRK1LMNA | |
| SCHEMBL7654887 | 0.81 | ALOX5 (0.68) | ALOX5PIK3CDHDAC1HDAC6HRH3 | |
| SCHEMBL332226 | 0.79 | ALOX5 (0.66) | ALOX5PIK3CDHDAC1HRH3ALDH1A1 | |
| SCHEMBL9440523 | 0.79 | ALOX5 (0.65) | ALOX5 | |
| SCHEMBL332479 | 0.79 | ALOX5 (0.65) | ALOX5PIK3CDHRH3ALDH1A1LMNA | |
| SCHEMBL8166180 | 0.78 | ALOX5 (0.67) | ALOX5PIK3CDHRH3ALDH1A1LMNA | |
| SCHEMBL7656075 | 0.78 | ALOX5 (0.69) | ALOX5PIK3CDALDH1A1LMNATSHR | |
| SCHEMBL7653236 | 0.77 | ALOX5 (0.68) | ALOX5PIK3CDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787127-B1 | 5-LIPOXYGENASE INHIBITORS | PFIZER (US) | 2001-01-03 | — | — | EP | claimed |
| EP-0787127-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1997-08-06 | — | — | EP | claimed |
| WO-1996011911-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | claimed |
| EP-0787127-B1 | 5-LIPOXYGENASE INHIBITORS | PFIZER (US) | 2001-01-03 | — | — | EP | disclosed |
| US-6063928-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, CARDIOTONIC AGENTS | PFIZER INC (US) | 2000-05-16 | — | — | US | disclosed |
| EP-0787127-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996011911-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | disclosed |