Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1039275 | 0.77 | CYP11B1 (0.41) | SIRT2 | |
| SCHEMBL7809133 | 0.74 | SIRT2 (0.34) | SIRT2 | |
| SCHEMBL7809080 | 0.72 | MAPT (0.34) | — | |
| SCHEMBL7816830 | 0.68 | SIRT2 (0.35) | SIRT2 | |
| SCHEMBL4025463 | 0.67 | CYP11B1 (0.39) | SIRT2 | |
| SCHEMBL7809232 | 0.67 | CYP11B1 (0.33) | SIRT2 | |
| SCHEMBL6965789 | 0.67 | CYP11B1 (0.33) | SIRT2 | |
| SCHEMBL6965487 | 0.67 | SIRT2 (0.33) | SIRT2 | |
| SCHEMBL8803490 | 0.66 | CYP11B1 (0.43) | SIRT2 | |
| SCHEMBL17651947 | 0.66 | SIRT2 (0.36) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889891-B1 | 4-[(THIEN-2-YL)METHYL]IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO MCNEIL PHARM INC (US) | 2001-06-06 | — | — | EP | disclosed |
| EP-0889891-A1 | 4-[(THIEN-2-YL)METHYL]IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO PHARMACEUTICAL CORPORATION (US) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997035857-A1 | 4-[(THIEN-2-YL)METHYL]IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |
| US-5621113-A | ALPHA 2 ADRENOCEPTOR AGONISTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |