SCHEMBL780924

SCHEMBL780924

c1ccc(-c2c3ccccc3c(-c3ccc(-n4c5ccc(-c6cccc7c6sc6c(-c8ccc9ccccc9c8)cccc67)cc5c5cc(-c6cccc7c6sc6c(-c8ccc9ccccc9c8)cccc67)ccc54)cc3)c3ccccc23)cc1

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
S1PR5 Q9H228 13/20 0.37
S1PR4 O95977 11/20 0.36
ALOX5 P09917 1/20 0.36
HDAC4 P56524 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
GPR84 Q9NQS5 1/20 0.34
GSTP1 P09211 1/20 0.33
LIMK1 P53667 1/20 0.32
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
KDM4E B2RXH2 1/20 0.32
ATM Q13315 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL780896 0.98 KDM4E (0.36) S1PR5S1PR4ALOX5HDAC4HDAC2
SCHEMBL780945 0.93 CYP1A1 (0.35) S1PR5S1PR4ALOX5GPR84LIMK1
SCHEMBL780929 0.93 ALOX5 (0.36) S1PR5S1PR4ALOX5LIMK1KDM4E
SCHEMBL781260 0.93 ALOX5 (0.45) S1PR5S1PR4ALOX5GPR84
SCHEMBL780673 0.92 ALOX5 (0.39) ALOX5HDAC4LIMK1KDM4EATM
SCHEMBL781140 0.91 KDM4E (0.35) S1PR5S1PR4ALOX5LIMK1ESR1
SCHEMBL780938 0.91 KDM4E (0.36) S1PR5ALOX5HDAC4LIMK1KDM4E
SCHEMBL780818 0.91 ALOX5 (0.36) S1PR5S1PR4ALOX5GPR84LIMK1
SCHEMBL781280 0.91 ALOX5 (0.39) ALOX5HDAC4LIMK1KDM4EATM
SCHEMBL780873 0.90 ALOX5 (0.38) S1PR5S1PR4ALOX5HDAC4LIMK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-12-29 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 S1PR5 4544/4885S1PR4 4453/4885ALOX5 1162/4885
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 S1PR5 4544/4885S1PR4 4453/4885ALOX5 1162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.