SCHEMBL7809251

SCHEMBL7809251

O=c1cc(-c2ccncc2)c2ccc(Br)cc2o1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA9 Q16790 8/20 0.50
CA12 O43570 7/20 0.50
AKR1B1 P15121 2/20 0.50
MAOB P27338 2/20 0.50
ALDH2 P05091 1/20 0.50
MAOA P21397 1/20 0.50
HSD17B3 P37058 1/20 0.50
SORD Q00796 1/20 0.50
KMT2A Q03164 1/20 0.48
IMPDH2 P12268 1/20 0.48
NOD2 Q9HC29 1/20 0.45
MCL1 Q07820 1/20 0.44
PIM1 P11309 1/20 0.44
LMNA P02545 1/20 0.44
CYP19A1 P11511 1/20 0.43
ALDH1A1 P00352 3/20 0.42
HPGD P15428 3/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
QPCT Q16769 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30228183 0.86 CA9 (0.68) CA9CA12AKR1B1MAOBALDH2
SCHEMBL2979482 0.86 CA9 (0.68) CA9CA12AKR1B1MAOBALDH2
SCHEMBL2991679 0.84 CA9 (0.51) CA9CA12AKR1B1MAOBALDH2
SCHEMBL7813458 0.83 CA9 (0.69) CA9CA12AKR1B1MAOBALDH2
SCHEMBL2985971 0.83 CA12 (0.50) CA9CA12AKR1B1MAOBALDH2
SCHEMBL8976932 0.82 CA9 (0.44) CA9CA12AKR1B1MAOBALDH2
SCHEMBL5085649 0.81 CA12 (0.75) CA9CA12AKR1B1MAOBALDH2
SCHEMBL7808379 0.79 ALOX5 (0.47) CA9CA12AKR1B1MAOBALDH2
SCHEMBL29182639 0.79 CA9 (0.54) CA9CA12AKR1B1MAOBALDH2
SCHEMBL9009056 0.78 CA9 (0.43) CA9CA12AKR1B1MAOBALDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0788497-B1 BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC (CA) 2001-05-23 EP disclosed
EP-0788490-B1 BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC (CA) 2000-07-05 EP disclosed
EP-0788497-A1 BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1997-08-13 EP disclosed
EP-0788490-A1 BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1997-08-13 EP disclosed
US-5552437-A ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY, AND CYTOPROTECTIVE AGENTS MERCK FROSST CANADA, INC. (CA) 1996-09-03 US disclosed
WO-1996013491-A1 BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1996-05-09 WO disclosed
WO-1996013500-A1 BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1996-05-09 WO disclosed