Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 13/20 | 0.71 |
| ▸ | CA2 | P00918 | 1/20 | 0.67 |
| ▸ | NCF1 | P14598 | 1/20 | 0.67 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MC4R | P32245 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL270535 | 0.93 | LMNA (0.62) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL797985 | 0.90 | ALDH1A1 (0.59) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL10212101 | 0.86 | HRH3 (0.65) | NCF1KDM4ESIGMAR1ALDH1A1 | |
| SCHEMBL1044315 | 0.86 | KCNH2 (0.58) | KDM4ELMNASIGMAR1ALDH1A1 | |
| SCHEMBL2056180 | 0.86 | CHKA (0.91) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL270997 | 0.84 | HRH3 (0.69) | NCF1KDM4ESIGMAR1ALDH1A1 | |
| SCHEMBL12666600 | 0.84 | HRH3 (0.69) | NCF1KDM4ESIGMAR1ALDH1A1 | |
| SCHEMBL16121577 | 0.83 | CHKA (1.00) | CHKACA2NCF1PRMT6KDM4E | |
| Hydrochloric Acid SCHEMBL7407307 | 0.83 | HRH3 (0.67) | NCF1KDM4ESIGMAR1ALDH1A1 | |
| SCHEMBL17470856 | 0.82 | KCNH2 (0.49) | CHKACA2NCF1PRMT6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140880-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | claimed |
| WO-2000039110-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | claimed |
| EP-1140880-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039110-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |