Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CRHBP | P24387 | 2/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3572935 | 0.95 | ALDH1A1 (0.60) | ALDH1A1MAPK1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL7852374 | 0.86 | MAPK1 (0.62) | ALDH1A1MAPK1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL13343777 | 0.84 | ALDH1A1 (0.63) | ALDH1A1SPHK2SPHK1GBA1 | |
| SCHEMBL7651919 | 0.84 | MAPK1 (0.60) | ALDH1A1MAPK1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL24447814 | 0.84 | MAPK1 (0.59) | ALDH1A1MAPK1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL11990423 | 0.84 | MAPK1 (0.59) | ALDH1A1MAPK1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL9893059 | 0.81 | MAPK1 (0.56) | ALDH1A1MAPK1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL13215732 | 0.81 | ALDH1A1 (0.57) | ALDH1A1MAPK1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL5528159 | 0.81 | ALDH1A1 (1.00) | ALDH1A1CRHBPCRHR2SMN1; SMN2KDM4E | |
| SCHEMBL13343700 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MAPK1CRHBPCRHR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283769-A | Cyclobutane-pyridine sulfonamide compound | 绍兴市上虞区武汉理工大学高等研究院 | 2023-06-23 | — | — | CN | disclosed |
| EP-0673927-B1 | piperidines as anticholinergic agents | EISAI CO LTD (JP) | 2001-09-19 | — | — | EP | disclosed |
| EP-1116716-A1 | Piperidine and piperazine compounds for use in the treatment of Alzheimer | Eisai Co., Ltd. (JP) | 2001-07-18 | — | — | EP | disclosed |
| US-5654306-A | ALZHEIMER'S DISEASE; COGNITION ACTIVATORS; BRAIN AND PSYCHOLOGICAL DISORDERS | EISAI CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| EP-0742207-A1 | 2-(Indan-1-one-2-yl-alkyl)-1-phenylalkyl-piperidines and processes for their preparation | Eisai Co., Ltd. (JP) | 1996-11-13 | — | — | EP | disclosed |
| EP-0673927-A1 | 4-[2-indanyl-1-one]alkylpiperidines as anticholinergic agents | Eisai Co., Ltd. (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5424318-A | Piperidine derivative and pharmaceutical composition | EISAI CO., LTD. (JP) | 1995-06-13 | — | — | US | disclosed |
| US-5306720-A | Treatment of cerebrovascular disorders | EISAI CO., LTD. (JP) | 1994-04-26 | — | — | US | disclosed |
| EP-0579263-A1 | 1,4-Substituted piperidines as acetylchozinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1994-01-19 | — | — | EP | disclosed |
| EP-0229391-B1 | PIPERIDINE DERIVATE, ITS USE AND PHARMACEUTICAL COMPOSITION CONTAINING IT | Eisai Co., Ltd. (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-5118684-A | For cardiovascular disorder | EISAI CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-5100901-A | Treatment of Alzheimer*s disease | EISAI CO., LTD. (JP) | 1992-03-31 | — | — | US | disclosed |
| US-5039681-A | Cognition activators, brain disorders, psychology | EISAI CO., LTD. (JP) | 1991-08-13 | — | — | US | disclosed |
| US-4942169-A | COGNITION ACTIVATORS, ANTICHOLINESTERASE | EISAI CO., LTD. (JP) | 1990-07-17 | — | — | US | disclosed |
| US-4895841-A | Cyclic amine compounds with activity against acetylcholinesterase | EISAI CO., LTD. (JP) | 1990-01-23 | — | — | US | disclosed |
| US-4849431-A | ANTICHOLINESTERASE ACTIVITY | EISAI CO., LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0296560-A2 | 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1988-12-28 | — | — | EP | disclosed |
| EP-0229391-A1 | Piperidine derivate, its use and pharmaceutical composition containing it | Eisai Co., Ltd. (JP) | 1987-07-22 | — | — | EP | disclosed |