Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817594 | 0.92 | KMT2A (0.52) | NOTUMKMT2AMEN1GAAPOLB | |
| SCHEMBL8564040 | 0.87 | P2RX4 (0.49) | KMT2AMEN1GAAPOLBALDH1A1 | |
| SCHEMBL8564035 | 0.87 | P2RX4 (0.49) | KMT2AMEN1GAAPOLBALDH1A1 | |
| SCHEMBL8564037 | 0.87 | P2RX4 (0.49) | KMT2AMEN1GAAPOLBALDH1A1 | |
| SCHEMBL7829862 | 0.84 | SIRT1 (0.49) | NOTUMKMT2APOLBALDH1A1 | |
| SCHEMBL7819461 | 0.82 | SIRT1 (0.47) | NOTUMKMT2APOLBALDH1A1 | |
| SCHEMBL7821003 | 0.82 | KMT2A (0.48) | KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL24377986 | 0.81 | KMT2A (0.55) | KMT2AMEN1GAAPOLBALDH1A1 | |
| SCHEMBL29516078 | 0.81 | KMT2A (0.55) | KMT2AMEN1GAAPOLBALDH1A1 | |
| SCHEMBL6973740 | 0.80 | POLB (0.54) | NOTUMKMT2AMEN1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894796-B1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR (FR) | 2001-06-06 | — | — | EP | disclosed |
| US-6057317-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 2000-05-02 | — | — | US | disclosed |
| EP-0894796-A1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |