Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 11/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819461 | 0.94 | SIRT1 (0.47) | SIRT1KMT2ASIRT2POLBALDH1A1 | |
| SCHEMBL7824177 | 0.90 | ALDH1A1 (0.47) | SIRT1KMT2APOLBALDH1A1TMEM97 | |
| SCHEMBL11567520 | 0.84 | SIRT1 (0.69) | SIRT1SIRT2POLB | |
| SCHEMBL7809581 | 0.84 | NOTUM (0.53) | KMT2APOLBALDH1A1NOTUM | |
| SCHEMBL7817475 | 0.84 | SIRT1 (0.50) | SIRT1KMT2ASIRT2POLBALDH1A1 | |
| SCHEMBL7817594 | 0.82 | KMT2A (0.52) | KMT2APOLBALDH1A1NOTUM | |
| SCHEMBL8564037 | 0.81 | P2RX4 (0.49) | SIRT1KMT2APOLBALDH1A1P2RX1 | |
| SCHEMBL8564040 | 0.81 | P2RX4 (0.49) | SIRT1KMT2APOLBALDH1A1P2RX1 | |
| SCHEMBL8564035 | 0.81 | P2RX4 (0.49) | SIRT1KMT2APOLBALDH1A1P2RX1 | |
| SCHEMBL7820037 | 0.78 | POLB (0.53) | SIRT1KMT2ASIRT2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894796-B1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR (FR) | 2001-06-06 | — | — | EP | disclosed |
| US-6057317-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 2000-05-02 | — | — | US | disclosed |
| EP-0894796-A1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |