SCHEMBL7809684

SCHEMBL7809684

COS(=O)(=O)Oc1c(C(C)=O)c(=O)[nH]c2c(Cl)cc(C)cc12

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GRIN1 Q05586 1/20 0.30
CAPN1 P07384 2/20 0.30
CTSL P07711 2/20 0.30
CTSB P07858 2/20 0.30
CTSH P09668 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7811062 0.89 KDM4E (0.35) GRIN1CAPN1CTSLCTSBCTSH
SCHEMBL7813848 0.87 CAPN1 (0.31) CAPN1CTSLCTSBCTSH
SCHEMBL7812985 0.84 MEN1 (0.32) GRIN1CAPN1CTSLCTSB
SCHEMBL7804023 0.82 TUBB4A (0.39) CAPN1
SCHEMBL7809685 0.81 RXFP1 (0.33) CAPN1CTSLCTSBCTSH
SCHEMBL7804000 0.79 CAPN1 (0.37) CAPN1
SCHEMBL7810949 0.77 CAPN1 (0.39) CAPN1CTSLCTSBCTSH
SCHEMBL7816785 0.77 CAPN1 (0.40) CAPN1CTSLCTSBCTSH
SCHEMBL7809496 0.76 KDM4E (0.43)
SCHEMBL7813881 0.74 GRIN2D (0.41) GRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0533882-B1 2-QUINOLINONE DERIVATIVES, METHODS FOR PREPARING THE SAME AND FUNGICIDES AND INSECTICIDES INCLUDING THEM KOREA RES INST CHEM TECH (KR) 2001-02-07 EP disclosed
US-5430153-A Insecticides, fungicides KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1995-07-04 US disclosed
EP-0533882-A1 2-QUINOLINONE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1993-03-31 EP disclosed
WO-1992017452-A1 2-QUINOLINONE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1992-10-15 WO disclosed