SCHEMBL7812985

SCHEMBL7812985

COS(=O)(=O)Oc1c(C(C)=O)c(=O)[nH]c2c(C)cc(Cl)cc12

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
CSF1R P07333 1/20 0.32
ALOX15 P16050 1/20 0.31
ABCB11 O95342 1/20 0.30
GRIN1 Q05586 1/20 0.30
CAPN1 P07384 1/20 0.30
CTSL P07711 1/20 0.30
CTSB P07858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7811062 0.89 KDM4E (0.35) CSF1RABCB11GRIN1CAPN1CTSL
SCHEMBL7804000 0.85 CAPN1 (0.37) CAPN1
SCHEMBL7809684 0.84 GRIN1 (0.30) GRIN1CAPN1CTSLCTSB
SCHEMBL7809496 0.81 KDM4E (0.43) MEN1KMT2A
SCHEMBL7812988 0.81 MEN1 (0.34) MEN1NPC1RAB9AKMT2ACSF1R
SCHEMBL7813848 0.81 CAPN1 (0.31) CAPN1CTSLCTSB
SCHEMBL7804023 0.78 TUBB4A (0.39) CAPN1
SCHEMBL7816785 0.77 CAPN1 (0.40) MEN1KMT2ACAPN1CTSLCTSB
SCHEMBL7810949 0.75 CAPN1 (0.39) MEN1KMT2ACAPN1CTSLCTSB
SCHEMBL8693274 0.74 ALOX15 (0.31) CSF1RALOX15CAPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0533882-B1 2-QUINOLINONE DERIVATIVES, METHODS FOR PREPARING THE SAME AND FUNGICIDES AND INSECTICIDES INCLUDING THEM KOREA RES INST CHEM TECH (KR) 2001-02-07 EP disclosed
US-5430153-A Insecticides, fungicides KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1995-07-04 US disclosed
EP-0533882-A1 2-QUINOLINONE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1993-03-31 EP disclosed
WO-1992017452-A1 2-QUINOLINONE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1992-10-15 WO disclosed