SCHEMBL7809771

SCHEMBL7809771

O=C(Cc1cc2ccccc2[nH]1)Nc1ccccc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 1/20 0.78
NPC1 O15118 1/20 0.57
LMNA P02545 1/20 0.57
RAB9A P51151 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
APP P05067 1/20 0.54
EPHX2 P34913 1/20 0.51
MTNR1A P48039 1/20 0.50
MTNR1B P49286 1/20 0.50
GSK3B P49841 1/20 0.49
LOXL2 Q9Y4K0 1/20 0.47
EGFR P00533 1/20 0.47
PIK3CA P42336 1/20 0.47
MPO P05164 1/20 0.47
IDO1 P14902 1/20 0.47
MIF P14174 1/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
KDM4E B2RXH2 1/20 0.46
MAPT P10636 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8889131 0.83 NLRP3 (0.59) NLRP3APPMTNR1AMTNR1BGSK3B
SCHEMBL28617787 0.82 NLRP3 (0.62) NLRP3LMNASMN1; SMN2GSK3BMEN1
SCHEMBL5498288 0.81 NLRP3 (0.60) NLRP3MTNR1AMTNR1BGSK3BLOXL2
SCHEMBL30730349 0.81 NLRP3 (0.60) NLRP3MTNR1AMTNR1BGSK3BLOXL2
SCHEMBL17327742 0.81 NLRP3 (0.60) NLRP3MTNR1AMTNR1BGSK3BLOXL2
SCHEMBL5668727 0.81 NLRP3 (0.56) NLRP3MTNR1AMTNR1BGSK3BLOXL2
SCHEMBL49270 0.80 LOXL2 (0.56) NLRP3NPC1LMNARAB9ASMN1; SMN2
SCHEMBL29365671 0.80 LOXL2 (0.56) NLRP3NPC1LMNARAB9ASMN1; SMN2
SCHEMBL31336079 0.80 LOXL2 (0.56) NLRP3NPC1LMNARAB9ASMN1; SMN2
SCHEMBL31511816 0.79 LOXL2 (0.55) NLRP3NPC1LMNARAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0953872-B1 Photographic element containing improved acylacetamido yellow dye-forming coupler EASTMAN KODAK CO (US) 2001-08-22 EP disclosed
US-5998107-A TRIAZINE DERIVATIVE OF A 3-INDOLOACETANILIDE EASTMAN KODAK COMPANY (US) 1999-12-07 US disclosed
EP-0953872-A1 Photographic element containing improved acylacetamido yellow dye-forming coupler EASTMAN KODAK COMPANY (US) 1999-11-03 EP disclosed