Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.72 |
| ▸ | CLK2 | P49760 | 3/20 | 0.72 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.72 |
| ▸ | PIM1 | P11309 | 3/20 | 0.72 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.72 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.72 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.72 |
| ▸ | CDK2 | P24941 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.72 |
| ▸ | CASP1 | P29466 | 2/20 | 0.72 |
| ▸ | CASP7 | P55210 | 2/20 | 0.72 |
| ▸ | KIT | P10721 | 2/20 | 0.72 |
| ▸ | KDR | P35968 | 2/20 | 0.72 |
| ▸ | FLT3 | P36888 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | CDC7 | O00311 | 1/20 | 0.72 |
| ▸ | PLK4 | O00444 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817760 | 0.94 | PIM1 (0.72) | TTKCLK2DYRK1APIM1MAPK8 | |
| SCHEMBL170980 | 0.84 | ALDH1A1 (1.00) | TTKCLK2DYRK1APIM1MAPK8 | |
| SCHEMBL29693577 | 0.84 | ALDH1A1 (1.00) | TTKCLK2DYRK1APIM1MAPK8 | |
| SCHEMBL29941507 | 0.84 | ALDH1A1 (1.00) | TTKCLK2DYRK1APIM1MAPK8 | |
| SCHEMBL8866586 | 0.83 | TTK (0.73) | TTKCLK2DYRK1APIM1MAPK8 | |
| SCHEMBL9201258 | 0.76 | MEN1 (0.67) | TTKCLK2DYRK1APIM1MAPK8 | |
| SCHEMBL8796647 | 0.76 | MEN1 (0.67) | TTKCLK2DYRK1APIM1MAPK8 | |
| SCHEMBL9115256 | 0.74 | TTK (0.64) | TTKCLK2DYRK1APIM1MAPK8 | |
| SCHEMBL8336855 | 0.72 | CDK2 (0.65) | TTKCLK2DYRK1APIM1MAPK8 | |
| SCHEMBL1296328 | 0.72 | TTK (0.65) | TTKCLK2DYRK1APIM1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | claimed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | claimed |
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| EP-0662076-B1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | UNIV VERMONT (US) | 2001-04-11 | — | — | EP | disclosed |
| US-5604246-A | HAVING POTENCY AGAINST MULTIDRUG RESISTANT TUMORS | BOEHRINGER MANNHEIM ITALIA SPA (IT) | 1997-02-18 | — | — | US | disclosed |
| US-5604246-A | HAVING POTENCY AGAINST MULTIDRUG RESISTANT TUMORS | BOEHRINGER MANNHEIM ITALIA SPA (IT) | 1997-02-18 | — | — | US | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0750619-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) | 1997-01-02 | — | — | EP | disclosed |
| US-5519029-A | ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1996-05-21 | — | — | US | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |
| EP-0662076-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1995-07-12 | — | — | EP | disclosed |
| WO-1994006795-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1994-03-31 | — | — | WO | disclosed |