Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.67 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | TTK | P33981 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | CDC7 | O00311 | 1/20 | 0.67 |
| ▸ | PLK4 | O00444 | 1/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.67 |
| ▸ | IKBKB | O14920 | 1/20 | 0.67 |
| ▸ | RGS12 | O14924 | 1/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | GAK | O14976 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.67 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.67 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796647 | 0.88 | MEN1 (0.67) | MEN1KMT2AMAPK8MAPK9MAPK10 | |
| SCHEMBL9115256 | 0.86 | TTK (0.64) | MEN1KMT2AMAPK8MAPK9MAPK10 | |
| SCHEMBL29941507 | 0.80 | ALDH1A1 (1.00) | MEN1KMT2AMAPK8MAPK9MAPK10 | |
| SCHEMBL29693577 | 0.80 | ALDH1A1 (1.00) | MEN1KMT2AMAPK8MAPK9MAPK10 | |
| SCHEMBL170980 | 0.80 | ALDH1A1 (1.00) | MEN1KMT2AMAPK8MAPK9MAPK10 | |
| SCHEMBL8866586 | 0.76 | TTK (0.73) | MEN1KMT2AMAPK8MAPK9MAPK10 | |
| SCHEMBL7817760 | 0.76 | PIM1 (0.72) | MEN1KMT2AMAPK8MAPK9MAPK10 | |
| SCHEMBL7810309 | 0.76 | TTK (0.72) | MEN1KMT2AMAPK8MAPK9MAPK10 | |
| SCHEMBL18216956 | 0.74 | TTK (0.60) | MEN1KMT2AMAPK8MAPK9MAPK10 | |
| SCHEMBL7946079 | 0.74 | KDR (0.65) | MEN1KMT2AMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662076-A1 | 2-AMINOALKYL-5-AMINOALKYLAMINO SUBSTITUTED ISOQUINOINDAZOLE-6-(2H)-ONES WITH ANTITUMOUR ACTIVITY | THE UNIVERSITY OF VERMONT (US) | 1995-07-12 | — | — | EP | disclosed |