Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 4/20 | 0.64 |
| ▸ | KDR | P35968 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.64 |
| ▸ | LCK | P06239 | 3/20 | 0.64 |
| ▸ | CSF1R | P07333 | 3/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | KIT | P10721 | 2/20 | 0.64 |
| ▸ | FLT3 | P36888 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | PLK4 | O00444 | 2/20 | 0.64 |
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9201258 | 0.86 | MEN1 (0.67) | TTKKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL8796647 | 0.86 | MEN1 (0.67) | TTKKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL29941507 | 0.78 | ALDH1A1 (1.00) | TTKKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL170980 | 0.78 | ALDH1A1 (1.00) | TTKKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL29693577 | 0.78 | ALDH1A1 (1.00) | TTKKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL8866586 | 0.74 | TTK (0.73) | TTKKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL7817760 | 0.74 | PIM1 (0.72) | TTKKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL7810309 | 0.74 | TTK (0.72) | TTKKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL7946079 | 0.72 | KDR (0.65) | TTKKDRALDH1A1MAPK8MAPK9 | |
| SCHEMBL1296328 | 0.72 | TTK (0.65) | TTKKDRALDH1A1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | claimed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |