Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MGAM | O43451 | 4/20 | 0.46 |
| ▸ | SI | P14410 | 4/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787611 | 0.74 | MAOB (0.65) | GAAMAPTMAOBMAOARAB9A | |
| SCHEMBL7813895 | 0.74 | ABCB1 (0.53) | MAOBPDGFRBPDGFRA | |
| SCHEMBL6701157 | 0.73 | MAOB (0.61) | GAAMAPTMAOBSMN1; SMN2L3MBTL1 | |
| SCHEMBL7810163 | 0.73 | MAOB (0.47) | MAOBL3MBTL1PDGFRBPDGFRA | |
| SCHEMBL7689083 | 0.72 | MAPT (0.59) | GAAMAPTMAOBMAOARAB9A | |
| SCHEMBL27998563 | 0.72 | MAOB (0.59) | GAAMAOBSMN1; SMN2MGAMSI | |
| SCHEMBL3789328 | 0.72 | MAOB (0.65) | GAAMAPTMAOBMAOARAB9A | |
| SCHEMBL96618 | 0.71 | ALOX5 (0.52) | GAAMAPTMAOBMAOARAB9A | |
| SCHEMBL5045790 | 0.71 | MAOB (0.89) | GAAMAPTMAOBMAOARAB9A | |
| SCHEMBL18411548 | 0.71 | GAA (0.65) | GAAMAPTMAOBSMN1; SMN2MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163225-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055137-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |