Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 10/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810163 | 0.90 | MAOB (0.47) | ABCB1HTR1ADRD2ABCG2MAOB | |
| SCHEMBL6701157 | 0.77 | MAOB (0.61) | ABCB1HTR1ADRD2MAOBBCHE | |
| SCHEMBL27998563 | 0.76 | MAOB (0.59) | HTR1AMAOBBCHEPDGFRBPDGFRA | |
| SCHEMBL96618 | 0.75 | ALOX5 (0.52) | HTR1ADRD2MAOBBCHE | |
| SCHEMBL6987612 | 0.75 | MAOB (0.58) | MAOBBCHEPDGFRBPDGFRA | |
| SCHEMBL25282560 | 0.74 | MAOB (0.57) | HTR1AMAOBBCHEPDGFRBPDGFRA | |
| SCHEMBL6696628 | 0.74 | MAOB (0.57) | ABCB1HTR1ADRD2MAOBBCHE | |
| SCHEMBL7811199 | 0.74 | GAA (0.50) | MAOBPDGFRBPDGFRA | |
| SCHEMBL2094271 | 0.72 | MAOB (0.59) | ABCB1HTR1ADRD2MAOBPDGFRB | |
| SCHEMBL4599002 | 0.72 | MAOB (0.54) | HTR1AMAOBPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163225-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055137-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |