Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | PLAU | P00749 | 4/20 | 0.41 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.41 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.39 |
| ▸ | HTR3B | O95264 | 5/20 | 0.39 |
| ▸ | HTR3A | P46098 | 5/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.38 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.38 |
| ▸ | SLC22A3 | O75751 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL7813154 | 0.84 | HTR3E (0.46) | ALDH1A1PLAUHTR3EHTR3BHTR3A | |
| Nitric Acid SCHEMBL3221126 | 0.81 | PLAU (0.41) | ALDH1A1PLAULMNASMN1; SMN2MPO | |
| Nitric Acid SCHEMBL1718 | 0.81 | ALDH1A1 (0.53) | ALDH1A1PLAULMNAPOLBSMN1; SMN2 | |
| Nitric Acid SCHEMBL7804174 | 0.81 | HTR3E (0.63) | ALDH1A1PLAUHTR3EHTR3BHTR3A | |
| SCHEMBL2694958 | 0.78 | ALDH1A1 (0.55) | ALDH1A1PLAULMNAPOLBSMN1; SMN2 | |
| Nitric Acid SCHEMBL1587377 | 0.77 | PLAU (0.59) | ALDH1A1PLAUHTR3EHTR3BHTR3A | |
| Nitric Acid SCHEMBL1587382 | 0.77 | PLAU (0.59) | ALDH1A1PLAUHTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL14763718 | 0.76 | ALDH1A1 (0.54) | ALDH1A1PLAULMNAPOLBSMN1; SMN2 | |
| SCHEMBL11346799 | 0.75 | ALDH1A1 (0.56) | ALDH1A1NPFFR1NPFFR2HTR3EHTR3B | |
| SCHEMBL10592734 | 0.74 | ALDH1A1 (0.54) | ALDH1A1PLAUNPFFR1NPFFR2HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672041-B1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| CN-1047776-C | Pharmacologically active pyridine derivatives and processes for the preparation thereof | NOVARTIS AG (CH) | 1999-12-29 | — | — | CN | disclosed |
| US-5728708-A | ANTITUMOR AGENTS | NOVARTIS CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |
| CN-1115982-A | pyridine derivatives having pharmacological activity and preparation method thereof | CIBA GEIGY AG (CH) | 1996-01-31 | — | — | CN | disclosed |
| EP-0672041-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1995-09-20 | — | — | EP | disclosed |
| WO-1995009853-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CIBA-GEIGY AG (CH) | 1995-04-13 | — | — | WO | disclosed |