Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.38 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL7811356 | 0.81 | ALDH1A1 (0.60) | PLAUSIGMAR1ALDH1A1MPOSLC22A2 | |
| Nitric Acid SCHEMBL1718 | 0.81 | ALDH1A1 (0.53) | PLAUSIGMAR1ALDH1A1MAPTGRIN2D | |
| SCHEMBL2694958 | 0.78 | ALDH1A1 (0.55) | PLAUSIGMAR1ALDH1A1MAPTGRIN2D | |
| Nitric Acid SCHEMBL1587377 | 0.77 | PLAU (0.59) | PLAUSIGMAR1ALDH1A1GRIN2DGRIN3B | |
| Nitric Acid SCHEMBL1587382 | 0.77 | PLAU (0.59) | PLAUSIGMAR1ALDH1A1GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL14763718 | 0.76 | ALDH1A1 (0.54) | PLAUSIGMAR1ALDH1A1MAPTGRIN2D | |
| SCHEMBL9316468 | 0.74 | SIGMAR1 (0.63) | PLAUSIGMAR1MPOSLC22A2SLC22A1 | |
| SCHEMBL11876737 | 0.74 | PLAU (0.60) | PLAUSIGMAR1ALDH1A1SLC22A2SLC22A1 | |
| Nitric Acid SCHEMBL1833741 | 0.73 | PLAU (0.73) | PLAUSIGMAR1SLC22A2SLC22A1SLC22A3 | |
| Sulfuric Acid SCHEMBL21799347 | 0.73 | ALDH1A1 (0.51) | PLAUSIGMAR1ALDH1A1MAPTGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010014022-A1 | A PROCESS FOR THE PREPARATION OF IMATINIB | TEMAPHARM SP. Z O.O. (PL) | 2010-02-04 | — | — | WO | disclosed |