Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL10487157 | 0.96 | LMNA (0.43) | LMNATSHRALDH1A1 | |
| SCHEMBL10393867 | 0.89 | LMNA (0.43) | LMNATSHR | |
| Ethylene SCHEMBL11639180 | 0.84 | LMNA (0.39) | LMNATSHR | |
| SCHEMBL3635650 | 0.81 | MEN1 (0.33) | TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL11485155 | 0.81 | LMNA (0.63) | LMNATSHRALDH1A1 | |
| SCHEMBL2544428 | 0.80 | LMNA (0.50) | LMNATSHR | |
| SCHEMBL441891 | 0.80 | ALDH1A1 (0.34) | TSHRALDH1A1 | |
| Glutaral SCHEMBL7174412 | 0.77 | LMNA (0.57) | LMNATSHRALDH1A1 | |
| Butanal SCHEMBL264581 | 0.77 | ALDH1A1 (0.57) | LMNATSHRALDH1A1 | |
| Butanal SCHEMBL11750341 | 0.77 | ALDH1A1 (0.57) | LMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636623-B1 | Indole derivatives as 5-HT1- like agonists | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5863935-A | SYNTHESIS OF INDOLE DERIVATIVES OF HETEROCYCLIC COMPOUNDS FOR TREATMENT OF HEADACHES AND MIGRAINES | ZENECA LIMITED (GB) | 1999-01-26 | — | — | US | disclosed |
| EP-0486666-B1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | ZENECA LTD (GB) | 1997-08-13 | — | — | EP | disclosed |
| US-5466699-A | Indolyl compounds for treating migraine | BURROUGHS WELLCOME CO. (US) | 1995-11-14 | — | — | US | disclosed |
| US-5399574-A | 5-hydroxytryptamine agonists; vasoconstrictors | BURROUGHS WELLCOME CO. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0636623-A1 | Indole derivatives as 5-HT1- like agonists | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |
| EP-0486666-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS. | WELLCOME FOUND (GB) | 1992-05-27 | — | — | EP | disclosed |
| WO-1991018897-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-12 | — | — | WO | disclosed |
| US-4183866-A | USING PREREDUCED COPPER CHOMITE HYDROGENATION CATALYST | CHEVRON RESEARCH COMPANY (US) | 1980-01-15 | — | — | US | disclosed |