Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850930 | 0.92 | KDM4E (0.75) | KDM4EKMT2AOPRM1OGFRL1ALDH1A1 | |
| SCHEMBL17760582 | 0.85 | KDM4E (0.62) | KDM4EKMT2AOPRM1OGFRL1ALDH1A1 | |
| SCHEMBL3482945 | 0.85 | KDM4E (0.62) | KDM4EKMT2AOPRM1OGFRL1ALDH1A1 | |
| SCHEMBL21292841 | 0.83 | KDM4E (0.59) | KDM4EKMT2AOPRM1OGFRL1ALDH1A1 | |
| SCHEMBL7706563 | 0.82 | KDM4E (0.61) | KDM4EKMT2AOPRM1OGFRL1ALDH1A1 | |
| SCHEMBL1922261 | 0.82 | KDM4E (0.61) | KDM4EKMT2AOPRM1OGFRL1ALDH1A1 | |
| SCHEMBL7687272 | 0.82 | KDM4E (0.61) | KDM4EKMT2AOPRM1OGFRL1ALDH1A1 | |
| SCHEMBL1420044 | 0.82 | KDM4E (0.61) | KDM4EKMT2AOPRM1OGFRL1ALDH1A1 | |
| SCHEMBL7712450 | 0.82 | KDM4E (0.61) | KDM4EKMT2AOPRM1OGFRL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1894628 | 0.81 | KDM4E (0.60) | KDM4EKMT2AOPRM1OGFRL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859778-B1 | TETRAHYDROIMIDAZOPYRIDOINDOLEDIONES AS INHIBITORS OF cGMP SPECIFIC PDE | ICOS CORP (US) | 2001-12-19 | — | — | EP | disclosed |