Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.38 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812652 | 1.00 | DRD2 (0.44) | DRD2DRD4KDM4ETP53DPP4 | |
| SCHEMBL7821927 | 0.85 | DRD4 (0.60) | DRD2DRD4 | |
| SCHEMBL7821881 | 0.82 | DPP4 (0.45) | DRD2DRD4DPP4CHRM4 | |
| SCHEMBL7820126 | 0.80 | DRD4 (0.70) | DRD2DRD4KDM4ETP53 | |
| SCHEMBL7822562 | 0.78 | DRD4 (0.55) | DRD2DRD4 | |
| SCHEMBL31753332 | 0.77 | HRH3 (0.48) | KDM4ETP53DPP4NOTUMCHRNA10 | |
| SCHEMBL7820151 | 0.76 | DRD4 (0.52) | DRD2DRD4HRH3 | |
| SCHEMBL8665307 | 0.76 | DRD4 (0.52) | DRD2DRD4HRH3 | |
| SCHEMBL21135569 | 0.75 | MEN1 (0.47) | KDM4ETP53CHRNA10CHRNA9HRH3 | |
| SCHEMBL21136632 | 0.75 | MEN1 (0.47) | KDM4ETP53CHRNA10CHRNA9HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874849-B1 | 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO 1,2-A]PYRAZINE DERIVATIVES | PFIZER (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6284757-B1 | ANTISEROTINONE AGENT | PFIZER INC. | 2001-09-04 | — | — | US | disclosed |
| EP-0982030-A2 | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands | Pfizer Products Inc. (US) | 2000-03-01 | — | — | EP | disclosed |
| EP-0874849-A1 | 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO 1,2-A]PYRAZINE DERIVATIVES | PFIZER INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5714487-A | 2,7-substituted octahydro-pyrrolo 1,2-a!pyrazine derivatives | PFIZER INC. (US) | 1998-02-03 | — | — | US | disclosed |
| WO-1997023482-A1 | 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO[1,2-A]PYRAZINE DERIVATIVES | PFIZER INC. (US) | 1997-07-03 | — | — | WO | disclosed |