Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 13/20 | 0.52 |
| ▸ | DRD2 | P14416 | 12/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8665307 | 1.00 | DRD4 (0.52) | DRD4DRD2ALDH1A1NPY1RMEN1 | |
| SCHEMBL7822562 | 0.91 | DRD4 (0.55) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL7821927 | 0.87 | DRD4 (0.60) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL7820126 | 0.82 | DRD4 (0.70) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL7824302 | 0.78 | DRD4 (0.59) | DRD4DRD2NPY1RHTR1AHTR2A | |
| SCHEMBL8593821 | 0.77 | DRD4 (0.49) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL7811956 | 0.77 | DRD4 (0.49) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL8639098 | 0.77 | DRD2 (0.59) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL7811901 | 0.76 | DRD2 (0.44) | DRD4DRD2HRH3 | |
| SCHEMBL7812652 | 0.76 | DRD2 (0.44) | DRD4DRD2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874849-B1 | 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO 1,2-A]PYRAZINE DERIVATIVES | PFIZER (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6284757-B1 | ANTISEROTINONE AGENT | PFIZER INC. | 2001-09-04 | — | — | US | disclosed |
| EP-0982030-A2 | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands | Pfizer Products Inc. (US) | 2000-03-01 | — | — | EP | disclosed |
| EP-0874849-A1 | 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO 1,2-A]PYRAZINE DERIVATIVES | PFIZER INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5714487-A | 2,7-substituted octahydro-pyrrolo 1,2-a!pyrazine derivatives | PFIZER INC. (US) | 1998-02-03 | — | — | US | disclosed |
| WO-1997023482-A1 | 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO[1,2-A]PYRAZINE DERIVATIVES | PFIZER INC. (US) | 1997-07-03 | — | — | WO | disclosed |