Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 12/20 | 0.70 |
| ▸ | DRD2 | P14416 | 11/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821927 | 0.94 | DRD4 (0.60) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL8639098 | 0.87 | DRD2 (0.59) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL7812210 | 0.85 | DRD4 (0.69) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL7822562 | 0.85 | DRD4 (0.55) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL6908454 | 0.85 | DRD4 (0.69) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL7998001 | 0.85 | DRD4 (0.69) | DRD4DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL14502886 | 0.82 | DRD4 (1.00) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL5420435 | 0.82 | DRD4 (1.00) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL6846737 | 0.82 | DRD4 (1.00) | DRD4DRD2HTR1AHTR2A | |
| SCHEMBL7820151 | 0.82 | DRD4 (0.52) | DRD4DRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874849-B1 | 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO 1,2-A]PYRAZINE DERIVATIVES | PFIZER (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6284757-B1 | ANTISEROTINONE AGENT | PFIZER INC. | 2001-09-04 | — | — | US | disclosed |
| EP-0982030-A2 | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands | Pfizer Products Inc. (US) | 2000-03-01 | — | — | EP | disclosed |