Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.48 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3220088 | 0.79 | MAPK14 (0.55) | MAPK14RAF1KDM4EALDH1A1GAA | |
| SCHEMBL13487957 | 0.73 | MAPK14 (0.52) | MAPK14RAF1KDM4EALDH1A1GAA | |
| SCHEMBL10308264 | 0.73 | MAPK14 (0.49) | MAPK14RAF1KDM4EALDH1A1GAA | |
| SCHEMBL3220272 | 0.71 | MAPK14 (0.47) | MAPK14RAF1ALDH1A1NPSR1MAPT | |
| SCHEMBL16240346 | 0.68 | LMNA (0.42) | MAPK14RAF1KDM4EALDH1A1GAA | |
| SCHEMBL3539674 | 0.67 | MAPK14 (0.52) | MAPK14RAF1ALDH1A1NPSR1USP2 | |
| SCHEMBL10717450 | 0.67 | MAPT (0.49) | MAPK14RAF1KDM4EALDH1A1GAA | |
| SCHEMBL4423633 | 0.66 | MAPK14 (0.51) | MAPK14RAF1KDM4EALDH1A1GAA | |
| SCHEMBL13315128 | 0.66 | MAPK14 (0.49) | MAPK14RAF1KDM4EALDH1A1GAA | |
| SCHEMBL5775175 | 0.66 | ALDH1A1 (0.46) | MAPK14RAF1KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986382-A4 | RAF KINASE INHIBITORS | BAYER AG (US) | 2001-04-11 | — | — | EP | disclosed |
| EP-0986382-A1 | RAF KINASE INHIBITORS | Bayer Corporation (US) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998052559-A1 | RAF KINASE INHIBITORS | BAYER CORPORATION (US) | 1998-11-26 | — | — | WO | disclosed |