Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 8/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP5 | P51878 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10819405 | 0.94 | CHKA (0.57) | CHKAKDM4EALDH1A1CASP1CASP5 | |
| SCHEMBL8974017 | 0.90 | ALDH1A1 (0.60) | CHKAKDM4EALDH1A1CASP1CASP5 | |
| SCHEMBL18783072 | 0.88 | ALDH1A1 (0.56) | CHKAKDM4EALDH1A1POLBCASP1 | |
| SCHEMBL6028265 | 0.85 | ALDH1A1 (0.67) | KDM4EALDH1A1CASP1CASP5GAA | |
| SCHEMBL2056180 | 0.84 | CHKA (0.91) | CHKAKDM4EALDH1A1POLBCA2 | |
| SCHEMBL428016 | 0.84 | CHKA (0.52) | CHKAKDM4EALDH1A1CASP1CASP5 | |
| SCHEMBL6925369 | 0.84 | CHKA (0.52) | CHKAKDM4EALDH1A1CASP1CASP5 | |
| SCHEMBL31010361 | 0.83 | ALDH1A1 (0.70) | KDM4EALDH1A1CASP1CASP5GAA | |
| SCHEMBL29777509 | 0.83 | LMNA (0.53) | CHKAKDM4EALDH1A1CA2NCF1 | |
| SCHEMBL545449 | 0.83 | LMNA (0.53) | CHKAKDM4EALDH1A1CA2NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140880-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | claimed |
| WO-2000039110-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | claimed |
| EP-1140880-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039110-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |