Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 7/20 | 0.45 |
| ▸ | TDO2 | P48775 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812948 | 0.82 | IDO1 (0.52) | IDO1TDO2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL7805846 | 0.78 | IDO1 (0.48) | IDO1TDO2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL7811891 | 0.77 | IDO1 (0.55) | IDO1TDO2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL25028024 | 0.77 | ALDH1A1 (0.43) | CYP1A2CYP2C19ALDH1A1PTGS1PDE7A | |
| SCHEMBL7813124 | 0.74 | IDO1 (0.55) | IDO1TDO2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL7814769 | 0.74 | IDO1 (0.55) | IDO1TDO2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7808342 | 0.74 | IDO1 (0.55) | IDO1TDO2ALDH1A1PTGS1SMN1; SMN2 | |
| SCHEMBL7811413 | 0.73 | IDO1 (0.50) | IDO1TDO2NPC1RAB9A | |
| SCHEMBL7811743 | 0.70 | IDO1 (0.46) | IDO1TDO2ALDH1A1BCL2ALOX5 | |
| SCHEMBL27506922 | 0.70 | CYP1A2 (0.39) | CYP1A2CYP2C19ALDH1A1PTGS1PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | claimed |
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |