Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.67 |
| ▸ | ABL1 | P00519 | 3/20 | 0.67 |
| ▸ | BCR | P11274 | 3/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.63 |
| ▸ | CDK2 | P24941 | 3/20 | 0.61 |
| ▸ | CDK1 | P06493 | 2/20 | 0.61 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.59 |
| ▸ | SYK | P43405 | 1/20 | 0.59 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.58 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.58 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL7813855 | 0.97 | PIK3CA (0.65) | PIK3CAPIK3CGABL1BCRPIK3CB | |
| SCHEMBL3513778 | 0.87 | CAMK2D (0.73) | PIK3CAPIK3CGABL1BCRPIK3CB | |
| SCHEMBL2322043 | 0.87 | PIK3CG (0.70) | PIK3CAPIK3CGABL1BCRPIK3CB | |
| SCHEMBL2331086 | 0.87 | PIK3CG (0.70) | PIK3CAPIK3CGABL1BCRPIK3CB | |
| Hydrochloric Acid SCHEMBL16496538 | 0.86 | PIK3CG (0.69) | PIK3CAPIK3CGABL1BCRPIK3CB | |
| SCHEMBL27115444 | 0.86 | PIK3CA (0.69) | PIK3CAPIK3CGABL1BCRPIK3CB | |
| SCHEMBL7467324 | 0.85 | ABL1 (0.76) | PIK3CAPIK3CGABL1BCRPIK3CB | |
| SCHEMBL2330123 | 0.85 | PLK1 (0.56) | PIK3CAPIK3CGABL1BCRPIK3CB | |
| SCHEMBL2333324 | 0.84 | CDK2 (0.53) | PIK3CAPIK3CGABL1BCRPIK3CB | |
| SCHEMBL4892481 | 0.84 | CAMK2D (0.53) | PIK3CAPIK3CGABL1BCRPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672041-B1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| WO-1999035140-A1 | PYRIDINYLPYRIMIDINE AMINES AS IMMUNOGLOBULINE E (IgE) SYNTHESIS INHIBITORS | NOVARTIS AG (CH) | 1999-07-15 | — | — | WO | disclosed |
| US-5728708-A | ANTITUMOR AGENTS | NOVARTIS CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |
| EP-0672041-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1995-09-20 | — | — | EP | disclosed |
| WO-1995009853-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CIBA-GEIGY AG (CH) | 1995-04-13 | — | — | WO | disclosed |