SCHEMBL7813629

SCHEMBL7813629

Nc1c(I)cc(C(=O)OS(=O)(=O)c2cccc3c(NCCNC(=O)CI)cccc23)cc1I

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKAG1 P54619 1/20 0.34
PRKAA1 Q13131 1/20 0.34
PRKAB1 Q9Y478 1/20 0.34
CA12 O43570 2/20 0.33
CA9 Q16790 2/20 0.33
CA4 P22748 1/20 0.33
CA7 P43166 1/20 0.33
CA14 Q9ULX7 1/20 0.33
HDAC3 O15379 2/20 0.31
HDAC1 Q13547 2/20 0.31
HDAC2 Q92769 2/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
HDAC4 P56524 1/20 0.31
HDAC7 Q8WUI4 1/20 0.31
HDAC10 Q969S8 1/20 0.31
HDAC11 Q96DB2 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
HDAC9 Q9UKV0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7813627 0.84 PRKAG1 (0.39) PRKAG1PRKAA1PRKAB1CA12CA9
SCHEMBL25745 0.76 CA12 (0.44) PRKAG1PRKAA1PRKAB1CA12CA9
SCHEMBL29358898 0.76 CA12 (0.44) PRKAG1PRKAA1PRKAB1CA12CA9
SCHEMBL29355645 0.76 CA12 (0.44) PRKAG1PRKAA1PRKAB1CA12CA9
Sulfuric Acid SCHEMBL6255051 0.68 CA12 (0.62) CA12CA9CA4CA7CA14
SCHEMBL30038420 0.67 CA12 (0.47) CA12CA9CA4CA7CA14
SCHEMBL10603285 0.67 CA12 (0.47) CA12CA9CA4CA7CA14
SCHEMBL3931597 0.67 CA12 (0.68) CA12CA9CA4CA7CA14
SCHEMBL29564430 0.67 CA12 (0.68) CA12CA9CA4CA7CA14
SCHEMBL22793508 0.66 TTR (0.43) PRKAG1PRKAA1PRKAB1CA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1091958-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2001-04-18 EP disclosed
WO-2000001692-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2000-01-13 WO disclosed