Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 6/20 | 0.65 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.65 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.65 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.65 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.45 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.45 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.41 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.40 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 10/20 | 0.65 |
| ▸ | HTR1D | P28221 | 9/20 | 0.65 |
| ▸ | HTR1F | P30939 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 2/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7813633 | 1.00 | HTR1B (0.65) | HTR1BHTR1DHTR1AHTR2AKMT2A | |
| Fumaric Acid SCHEMBL7813640 | 1.00 | HTR1B (0.65) | HTR1BHTR1DHTR1AHTR2AKMT2A | |
| SCHEMBL7817210 | 0.92 | HTR1D (0.74) | HTR1BHTR1DHTR1AHTR2AKMT2A | |
| SCHEMBL2739219 | 0.92 | HTR1D (0.74) | HTR1BHTR1DHTR1AHTR2AKMT2A | |
| Fumaric Acid SCHEMBL7813408 | 0.88 | HTR1D (0.65) | HTR1BHTR1DHTR1AHTR2AKMT2A | |
| Maleic Acid SCHEMBL7813403 | 0.88 | HTR1D (0.65) | HTR1BHTR1DHTR1AHTR2AKMT2A | |
| Fumaric Acid SCHEMBL7813410 | 0.88 | HTR1D (0.65) | HTR1BHTR1DHTR1AHTR2AKMT2A | |
| Maleic Acid SCHEMBL7815095 | 0.82 | HTR1B (0.68) | HTR1BHTR1DHTR1AHTR2AKMT2A | |
| Fumaric Acid SCHEMBL7815103 | 0.82 | HTR1B (0.68) | HTR1BHTR1DHTR1AHTR2AKMT2A | |
| Fumaric Acid SCHEMBL7815106 | 0.82 | HTR1B (0.68) | HTR1BHTR1DHTR1AHTR2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636623-B1 | Indole derivatives as 5-HT1- like agonists | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5466699-A | Indolyl compounds for treating migraine | BURROUGHS WELLCOME CO. (US) | 1995-11-14 | — | — | US | disclosed |
| US-5399574-A | 5-hydroxytryptamine agonists; vasoconstrictors | BURROUGHS WELLCOME CO. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0636623-A1 | Indole derivatives as 5-HT1- like agonists | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |