Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030635 | 0.87 | PTGS2 (0.62) | PTGS2PTGS1AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL7810450 | 0.85 | PTGS2 (0.58) | PTGS2PTGS1AKR1C3 | |
| SCHEMBL4321082 | 0.84 | ENPP2 (0.58) | PTGS2AKR1C3 | |
| SCHEMBL7810345 | 0.81 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL6583948 | 0.79 | PTGS2 (0.57) | PTGS2AKR1C3 | |
| SCHEMBL7813780 | 0.79 | MAOB (0.50) | PTGS2AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL1069077 | 0.78 | LTA4H (0.59) | — | |
| SCHEMBL7811336 | 0.78 | HDAC1 (0.50) | PTGS2PTGS1 | |
| SCHEMBL3468270 | 0.77 | ENPP2 (0.75) | PTGS2ESR1 | |
| SCHEMBL6583952 | 0.77 | PTGS2 (0.65) | PTGS2AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891345-B1 | NOVEL FURAN DIARYLMETHYLIDENE DERIVATIVES, METHOD FOR THEIR PREPARATION AND THERAPEUTICAL USES THEREOF | UNION PHARMA SCIENT APPL (FR) | 2001-08-16 | — | — | EP | disclosed |
| US-6180651-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | BRISTOL-MYERS SQUIBB | 2001-01-30 | — | — | US | disclosed |
| WO-2000014082-A1 | DIARYLMETHYLIDENE FURAN DERIVATIVES AS DRUGS WITH ANTI-INFLAMMATORY, ANALGESIC AND CHEMOPREVENTIVE PROPERTIES | LABORATORIES UPSA (FR) | 2000-03-16 | — | — | WO | disclosed |
| EP-0891345-A1 | NOVEL FURAN DIARYLMETHYLIDENE DERIVATIVES, METHOD FOR THEIR PREPARATION AND THERAPEUTICAL USES THEREOF | LABORATOIRES UPSA (FR) | 1999-01-20 | — | — | EP | disclosed |
| US-5807873-A | Diarylmethylidenefuran derivatives and their uses in therapeutics | LABORATORIES UPSA (FR) | 1998-09-15 | — | — | US | disclosed |
| WO-1997037984-A1 | NOVEL FURAN DIARYLMETHYLIDENE DERIVATIVES, METHOD FOR THEIR PREPARATION AND THERAPEUTICAL USES THEREOF | LABORATOIRES UPSA (FR) | 1997-10-16 | — | — | WO | disclosed |