Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965741 | 0.90 | HTR1A (0.54) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL7887623 | 0.86 | ABCB1 (0.61) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL5584644 | 0.86 | HTR1A (0.59) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| Hydrochloric Acid SCHEMBL10673906 | 0.84 | HTR1A (0.47) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL6621730 | 0.83 | TDP1 (0.48) | HTR1ASLC6A4MEN1KMT2ATDP1 | |
| SCHEMBL7953370 | 0.83 | HTR1A (0.56) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL7876417 | 0.83 | HTR1A (0.60) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| Oxalic Acid SCHEMBL7814401 | 0.82 | HTR1A (0.55) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL7881059 | 0.82 | HTR1A (0.58) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL7883042 | 0.82 | HTR1A (0.54) | HTR1ASLC6A4ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0814084-B1 | Indole derivative as 5-HT1A antagonist and as inhibitor of serotonine reuptake | LILLY CO ELI (US) | 2001-08-08 | — | — | EP | disclosed |
| US-5912256-A | 0-(4-INDOLYLOXY)-3-(4-HYDROXY-4-NAPHTHYLPIPERIDIN-1-YL)PROPANE S | ELI LILLY AND COMPANY (US) | 1999-06-15 | — | — | US | disclosed |
| EP-0814084-A1 | Indole derivatives as 5-HT1A antagonists and as inhibitors of serotonine reuptake | ELI LILLY AND COMPANY (US) | 1997-12-29 | — | — | EP | disclosed |