Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205848 | 0.92 | MAPT (0.54) | MAPTALDH1A1TDP1MAPK1HTR6 | |
| SCHEMBL8139111 | 0.88 | MAPT (0.47) | MAPTALDH1A1MAPK1L3MBTL1MEN1 | |
| SCHEMBL7814569 | 0.79 | LMNA (0.51) | MAPTALDH1A1MAPK1L3MBTL1MEN1 | |
| SCHEMBL8203184 | 0.79 | BRD4 (0.56) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL27807398 | 0.78 | GRIA1 (0.49) | MAPTTSHRMEN1KMT2A | |
| SCHEMBL29486349 | 0.77 | ENPP2 (0.50) | MAPTPKM | |
| SCHEMBL2467753 | 0.75 | ALDH1A1 (0.56) | MAPTALDH1A1RAB9ATSHRTDP1 | |
| SCHEMBL20536197 | 0.74 | CYP19A1 (0.52) | MAPT | |
| SCHEMBL17630137 | 0.74 | GRIA1 (0.46) | MAPTTSHRMEN1KMT2A | |
| SCHEMBL1839319 | 0.74 | HPGD (0.51) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121264-A | GLUTAMATE RECEPTOR ANTAGONIST, AMPA RECEPTOR ANTAGONIST, NMDA-GLYCINE RECEPTOR ANTAGONIST, KAINIC ACID NEUROTOXICITY INHIBITOR, ANTIISCHEMIC AGENT, PSYCHOTROPIC AGENT | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| EP-0919554-A1 | IMIDAZOLE-SUBSTITUTED QUINOXALINEDIONE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1999-06-02 | — | — | EP | disclosed |