Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.51 |
| ▸ | TUBB | P07437 | 8/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811127 | 0.85 | EGFR (0.49) | ALDH1A1KDM4ESMN1; SMN2TUBB4ATUBB | |
| SCHEMBL8542367 | 0.80 | KDM4E (0.54) | ALDH1A1KDM4ESMN1; SMN2TUBB4ATUBB | |
| SCHEMBL7807575 | 0.78 | ALDH1A1 (0.73) | ALDH1A1KDM4ESMN1; SMN2HSD17B10HTT | |
| SCHEMBL7809220 | 0.76 | KDM4E (0.64) | ALDH1A1KDM4ESMN1; SMN2HSD17B10HTT | |
| SCHEMBL4065612 | 0.75 | KDM4E (0.72) | ALDH1A1KDM4ESMN1; SMN2HSD17B10HTT | |
| SCHEMBL377487 | 0.75 | ALDH1A1 (0.68) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL31192183 | 0.75 | ALDH1A1 (0.68) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8602933 | 0.75 | KDM4E (0.62) | ALDH1A1KDM4ESMN1; SMN2HSD17B10HTT | |
| SCHEMBL29045025 | 0.75 | KIF11 (0.62) | ALDH1A1KDM4ESMN1; SMN2TUBB4ATUBB | |
| SCHEMBL28813987 | 0.73 | TUBB4A (0.51) | ALDH1A1KDM4ESMN1; SMN2TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644878-B1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-09-12 | — | — | EP | disclosed |
| US-5712272-A | TREATMENT OF NEUROLOGICAL DISORDERS WITH BENZ(B)AZEPINE COMPOUNDS | ZENECA LIMITED (GB) | 1998-01-27 | — | — | US | disclosed |
| US-5654295-A | NEUROLOGICAL DISORDERS; BENZ(B0AZEPINE COMPOUNDS | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | disclosed |
| US-5492905-A | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 1996-02-20 | — | — | US | disclosed |
| WO-1993025534-A1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1993-12-23 | — | — | WO | disclosed |