⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814909 | 0.77 | — | — | |
| SCHEMBL5982858 | 0.69 | PDE10A (0.31) | — | |
| SCHEMBL1831006 | 0.69 | KMT2A (0.38) | — | |
| SCHEMBL7814921 | 0.68 | CYP11B1 (0.36) | — | |
| SCHEMBL2157981 | 0.67 | CYP11B1 (0.39) | — | |
| SCHEMBL21187466 | 0.67 | DPP4 (0.47) | — | |
| SCHEMBL20698307 | 0.67 | KEAP1 (0.35) | — | |
| SCHEMBL4272934 | 0.66 | TRPV4 (0.38) | — | |
| SCHEMBL7805132 | 0.64 | NQO2 (0.36) | — | |
| SCHEMBL7810993 | 0.63 | PRPS1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |