Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.53 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLQ | O75417 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 3/20 | 0.42 |
| ▸ | FNTB | P49356 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812086 | 0.90 | GABBR2 (0.50) | GABBR2GABBR1MAPTTACR1POLB | |
| SCHEMBL7812095 | 0.84 | TACR1 (0.47) | GABBR2GABBR1TACR1KMT2AMEN1 | |
| SCHEMBL7815224 | 0.83 | ALDH1A1 (0.52) | TACR1POLBKMT2AMEN1KDM4E | |
| SCHEMBL7809411 | 0.83 | TACR1 (0.44) | GABBR2GABBR1MAPTTACR1POLB | |
| SCHEMBL2222871 | 0.81 | ALDH1A1 (0.53) | GABBR2GABBR1MAPTPOLBKMT2A | |
| SCHEMBL503819 | 0.80 | GABBR2 (0.76) | GABBR2GABBR1MAPTPOLBKMT2A | |
| SCHEMBL1114991 | 0.80 | KMT2A (0.47) | TACR1POLBKMT2AMEN1KDM4E | |
| SCHEMBL1781861 | 0.79 | GABBR2 (0.51) | GABBR2GABBR1MAPTTACR1POLB | |
| Hydrochloric Acid SCHEMBL7092228 | 0.78 | GABBR2 (0.73) | GABBR2GABBR1MAPTPOLBKMT2A | |
| SCHEMBL6734410 | 0.78 | GABBR2 (0.73) | GABBR2GABBR1MAPTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773929-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2001-10-31 | — | — | EP | disclosed |
| US-5654316-A | Piperidine derivatives as neurokinin antagonists | SCHERING CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |