Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.53 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812090 | 0.90 | LMNA (0.60) | MAPTALDH1A1KDM4ERECQLHTT | |
| SCHEMBL2222874 | 0.84 | MAPT (0.56) | MAPTALDH1A1KDM4ERECQLHPGD | |
| SCHEMBL7815227 | 0.83 | FNTA (0.51) | MAPTALDH1A1RECQLHPGDHTT | |
| SCHEMBL7809414 | 0.83 | TACR1 (0.47) | MAPTALDH1A1KDM4EHPGDHTT | |
| SCHEMBL15571714 | 0.83 | HPGD (0.72) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL29050822 | 0.81 | MAPT (0.59) | MAPTALDH1A1KDM4ERECQLHPGD | |
| SCHEMBL503819 | 0.80 | GABBR2 (0.76) | MAPTKDM4ERECQLHTTSMN1; SMN2 | |
| SCHEMBL22636418 | 0.79 | GAA (0.54) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL22636419 | 0.79 | GAA (0.54) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL14027523 | 0.79 | POLB (0.61) | MAPTKDM4ERECQLHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773929-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2001-10-31 | — | — | EP | disclosed |
| US-5654316-A | Piperidine derivatives as neurokinin antagonists | SCHERING CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |