SCHEMBL7815751

SCHEMBL7815751

COC(=O)c1cccc(-c2ccccc2[N+](=O)[O-])c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 1/20 0.58
AKR1C4 P17516 1/20 0.53
AKR1C3 P42330 1/20 0.53
AKR1C2 P52895 1/20 0.53
AKR1C1 Q04828 1/20 0.53
ALDH1A1 P00352 2/20 0.53
TDP1 Q9NUW8 1/20 0.53
VCAM1 P19320 1/20 0.49
CA12 O43570 1/20 0.49
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
CA9 Q16790 1/20 0.49
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
LMNA P02545 2/20 0.47
RXFP1 Q9HBX9 1/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
PDK2 Q15119 1/20 0.47
AXL P30530 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13600570 0.89 ERN1 (0.53) ERN1AKR1C4AKR1C3AKR1C2AKR1C1
SCHEMBL13600549 0.89 ERN1 (0.53) ERN1AKR1C4AKR1C3AKR1C2AKR1C1
SCHEMBL5652491 0.85 ALDH1A1 (0.52) ALDH1A1TDP1KMT2ALMNANPC1
SCHEMBL4489440 0.84 NPC1 (0.69) ERN1AKR1C4AKR1C3AKR1C2AKR1C1
SCHEMBL5651714 0.84 ALDH1A1 (0.57) ERN1ALDH1A1TDP1VCAM1MEN1
SCHEMBL12777033 0.84 ERN1 (0.56) ERN1AKR1C4AKR1C3AKR1C2AKR1C1
SCHEMBL4492560 0.84 MAOB (0.49) ERN1AKR1C4AKR1C3AKR1C2AKR1C1
SCHEMBL12844722 0.83 ERN1 (0.55) ERN1AKR1C4AKR1C3AKR1C2AKR1C1
SCHEMBL28669741 0.82 ALDH1A1 (0.64) ERN1AKR1C4AKR1C3AKR1C2AKR1C1
SCHEMBL2484847 0.82 VCAM1 (0.57) ERN1ALDH1A1TDP1VCAM1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1080257-C Guanidine derivatives as inhibitors of Na+/H+ exchange in cells FUJISAWA PHARMACEUTICAL CO (JP) 2002-03-06 CN disclosed
EP-0699185-B1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+ /H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO (JP) 2001-09-05 EP disclosed
US-5824691-A CARDIOVASCULAR, CEREBROVASCULAR, RENAL DISEASES; SHOCK, ARTERIOSCLEROSIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-10-20 US disclosed
CN-1123545-A Guanidine derivatives as inhibitors of Na+/H+ exchange in cells FUJISAWA PHARMACEUTICAL CO (JP) 1996-05-29 CN disclosed
EP-0699185-A1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+ /H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-03-06 EP disclosed
WO-1994026709-A1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+/H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-11-24 WO disclosed