SCHEMBL7816355

SCHEMBL7816355

CSc1ncccc1C(=O)C(C(=O)OC(C)(C)C)C(=O)C1CC1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.44
L3MBTL1 Q9Y468 5/20 0.42
CASP3 P42574 2/20 0.42
SENP8 Q96LD8 2/20 0.42
SENP7 Q9BQF6 2/20 0.42
SENP6 Q9GZR1 2/20 0.42
TSHR P16473 2/20 0.42
ALDH1A1 P00352 4/20 0.42
HTT P42858 1/20 0.42
KMT2A Q03164 4/20 0.41
MEN1 O00255 3/20 0.41
LMNA P02545 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
NPC1 O15118 1/20 0.39
GLA P06280 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7706403 0.83 RAB9A (0.49) RAB9AL3MBTL1CASP3SENP8SENP7
SCHEMBL8493489 0.74 SLC6A2 (0.39) L3MBTL1ALDH1A1LMNA
SCHEMBL9116917 0.74 RAB9A (0.47) RAB9AL3MBTL1CASP3SENP8SENP7
SCHEMBL9195406 0.73 HPGD (0.37) RAB9ATSHRALDH1A1HTTNPC1
SCHEMBL7708491 0.73 SLC6A9 (0.36)
SCHEMBL8492357 0.72 HPGD (0.47) RAB9AL3MBTL1TSHRALDH1A1HTT
SCHEMBL6183222 0.72 GPR119 (0.30)
SCHEMBL9118267 0.71 EDNRA (0.37)
SCHEMBL6441376 0.71
SCHEMBL8493033 0.71 KMT2A (0.34) KMT2AMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1156048-A1 Heteroaroyl-isoxazoles and their use as herbicides RHONE-POULENC AGRICULTURE LTD. (GB) 2001-11-21 EP disclosed
US-5480857-A Herbicidal 4-heteroaroylisoxazole derivatives RHONE-POULENC AGRICULTURE LIMITED (GB) 1996-01-02 US disclosed
WO-1995025099-A1 2-CYANO-1,3-DIONE DERIVATIVES USEFUL AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1995-09-21 WO disclosed