Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 15/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | CCKAR | P32238 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7808538 | 0.91 | CCKBR (0.46) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4420773 | 0.88 | CCKBR (0.55) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9369171 | 0.88 | CCKBR (0.55) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7824899 | 0.77 | CCKBR (0.84) | CCKBR | |
| SCHEMBL7822828 | 0.76 | CCKBR (0.41) | CCKBR | |
| SCHEMBL6045947 | 0.75 | CCKBR (0.55) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4701528 | 0.75 | CCKBR (0.55) | CCKBRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4703983 | 0.75 | CCKBR (0.53) | CCKBR | |
| SCHEMBL7808154 | 0.73 | CCKBR (0.68) | CCKBRCCKARKCNH2 | |
| SCHEMBL7808638 | 0.73 | GABRP (0.55) | CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652871-B1 | BENZODIAZEPINE DERIVATIVES | MERCK SHARP & DOHME (GB) | 2001-10-17 | — | — | EP | disclosed |
| WO-1994003437-A1 | BENZODIAZEPINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |