Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2304410 | 0.79 | CPN1 (0.41) | DPP4DPP7KDM4E | |
| SCHEMBL7330630 | 0.74 | CPB1 (0.63) | KMT2AALDH1A1MAPK1 | |
| SCHEMBL2793009 | 0.74 | KMT2A (0.54) | KMT2AALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL25057228 | 0.73 | KMT2A (0.57) | KMT2AALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7288362 | 0.71 | ACHE (0.60) | ACHEKMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL12184236 | 0.70 | ALDH1A1 (0.62) | KMT2AALDH1A1MAPK1 | |
| SCHEMBL5481329 | 0.69 | ALDH1A1 (0.65) | KMT2AALDH1A1MAPK1 | |
| SCHEMBL11896993 | 0.69 | DPP4 (0.40) | DPP4DPP7KDM4E | |
| SCHEMBL4209611 | 0.69 | NPY5R (0.46) | ACHEKMT2AALDH1A1MAPK1TP53 | |
| SCHEMBL16050429 | 0.69 | TSHR (0.60) | KMT2ASLC6A2SLC6A3NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885218-B1 | OXA- AND THIA-DIAZOLE MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER RES AND (IE) | 2001-05-02 | — | — | EP | disclosed |
| US-5977142-A | Oxa-and thia-diazole muscarinic receptor antagonists | PFIZER INC. (US) | 1999-11-02 | — | — | US | disclosed |