Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7820400 | 0.92 | SRD5A2 (0.39) | PPARGPPARDPPARASRD5A2MAOB | |
| Acetic Acid SCHEMBL7807359 | 0.87 | MAOB (0.42) | SRD5A2MAOBNPC1RAB9AMEN1 | |
| Acetic Acid SCHEMBL7815433 | 0.86 | PPARG (0.40) | PPARGPPARDPPARASRD5A2MAOB | |
| Acetic Acid SCHEMBL7818759 | 0.85 | MAOB (0.40) | PPARGPPARDPPARASRD5A2MAOB | |
| SCHEMBL7654026 | 0.83 | CNR1 (0.38) | PPARGPPARDPPARASRD5A2MAOB | |
| Acetic Acid SCHEMBL7814541 | 0.83 | TP53 (0.38) | MAOBMEN1KMT2AIGF1RUSP2 | |
| Acetic Acid SCHEMBL7815788 | 0.82 | MAOB (0.41) | PPARGPPARDPPARASRD5A2MAOB | |
| SCHEMBL7851518 | 0.82 | PPARG (0.36) | PPARGPPARDPPARASRD5A2MAOB | |
| Acetic Acid SCHEMBL7814532 | 0.82 | TRPM8 (0.39) | SRD5A2MAOBCAMK2DIGF1RLMNA | |
| Acetic Acid SCHEMBL7817718 | 0.81 | CAMK2D (0.39) | PPARGPPARDPPARASRD5A2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010025043-A1 | New pharmaceutical active compounds | ASTRA AKTIEBOLAG, A SWEDEN CORPORATION | 2001-09-27 | — | — | US | disclosed |
| US-6271231-B1 | Pharmaceutically active compounds | ASTRA AKTIEBOLAG (SE) | 2001-08-07 | — | — | US | disclosed |
| EP-0929551-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | Astra Aktiebolag (publ) (SE) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013368-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRA AKTIEBOLAG (PUBL) (SE) | 1998-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010025043-A1 | New pharmaceutical active compounds | CSNK1A1, CSNK1G1, CSNK2A1 | PPARG 1726/4885PPARD 3007/4885PPARA 2806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.