Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Ethylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.30 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CCL2 | P13500 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL6918048 | 0.98 | HTR2A (0.39) | HTR2AHTR6BRD4CCL2CYP2D6 | |
| Ethylene SCHEMBL6914267 | 0.98 | HTR2A (0.35) | HTR2AHTR6BRD4CCL2CYP2D6 | |
| Ethylene SCHEMBL818950 | 0.96 | HTR2A (0.41) | HTR2AHTR6BRD4CCL2CYP2D6 | |
| Ethylene SCHEMBL6914314 | 0.96 | HTR2A (0.36) | HTR2AHTR6BRD4CCL2CYP2D6 | |
| Hydrochloric Acid SCHEMBL29424565 | 0.96 | HTR2A (0.39) | HTR2AHTR6BRD4CCL2CYP2D6 | |
| Hydrochloric Acid SCHEMBL137960 | 0.96 | HTR2A (0.39) | HTR2AHTR6BRD4CCL2CYP2D6 | |
| Ethylene SCHEMBL6917717 | 0.94 | BRD4 (0.34) | HTR2AHTR6BRD4CCL2CYP2D6 | |
| Hydrochloric Acid SCHEMBL820052 | 0.94 | HTR2A (0.38) | HTR2AHTR6BRD4CCL2CYP2D6 | |
| Hydrochloric Acid SCHEMBL30533388 | 0.94 | HTR2A (0.38) | HTR2AHTR6BRD4CCL2CYP2D6 | |
| SCHEMBL31357303 | 0.94 | HTR2A (0.40) | HTR2AHTR6BRD4CCL2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 439 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240076422-A1 | SUPPORTED METALLOCENE CATALYST, METHOD FOR PREPARING THE SAME, AND USE OF THE SAME FOR PREPARING POLYOLEFIN | NATIONAL CHUNG CHENG UNIVERSITY (TW) | 2024-03-07 | — | — | US | claimed |
| US-9540466-B2 | Ethylene-based quaterpolymer having low glass transition temperature and preparation method thereof | KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY (KR) | 2017-01-10 | — | — | US | claimed |
| EP-2160233-B1 | PROCESS FOR THE POLYMERISATION OF OLEFINS | TOTAL RES & TECHNOLOGY FELUY (BE) | 2012-10-17 | — | — | EP | claimed |
| US-7807096-B2 | Injection blow molded single layer metallocene polyethylene container | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2010-10-05 | — | — | US | claimed |
| US-20100234544-A1 | Process for the Polymerisation of Olefins | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2010-09-16 | — | — | US | claimed |
| EP-2160233-A1 | PROCESS FOR THE POLYMERISATION OF OLEFINS | Total Petrochemicals Research Feluy (BE) | 2010-03-10 | — | — | EP | claimed |
| WO-2009000782-A1 | PROCESS FOR THE POLYMERISATION OF OLEFINS | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2008-12-31 | — | — | WO | claimed |
| EP-2006012-A1 | Process for the polymerisation of olefins | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2008-12-24 | — | — | EP | claimed |
| US-20060269709-A1 | Metallocene-produced polyethylene for injection blow moulding | ATOFINA RESEARCH | 2006-11-30 | — | — | US | claimed |
| US-20050037166-A1 | Injection blow moulded single layer metallocene polyethylene container | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2005-02-17 | — | — | US | claimed |
| US-6127305-A | Catalyst and process for polymerizing alpha-olefins | ENICHEM S.P.A (IT) | 2000-10-03 | — | — | US | claimed |
| EP-0720989-B1 | Continuous process for the (co)polymerization of ethylene | ENICHEM SPA (IT) | 1999-09-01 | — | — | EP | claimed |
| EP-0824554-A1 | AMORPHOUS OLEFIN CO/TER-POLYMERS | OPTATECH CORPORATION (FI) | 1998-02-25 | — | — | EP | claimed |
| EP-0588404-B1 | Catalyst and process for polymerizing alpha-olefins | ENICHEM SPA (IT) | 1997-06-18 | — | — | EP | claimed |
| WO-1996035730-A1 | AMORPHOUS OLEFIN CO/TER-POLYMERS | OPTATECH CORPORATION (FI) | 1996-11-14 | — | — | WO | claimed |
| EP-0588404-A2 | Catalyst and process for polymerizing alpha-olefins | ENICHEM S.p.A. (IT) | 1994-03-23 | — | — | EP | claimed |
| US-5204419-A | Using a coordination catalyst comprising an alumoxane and a transition metal compound containing cycloalkadiene or indane rings | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1993-04-20 | — | — | US | claimed |
| EP-0303519-B1 | POLYMERIZATION OF ETHYLENE | MITSUBISHI PETROCHEMICAL CO., LTD. (JP) | 1993-03-31 | — | — | EP | claimed |
| US-4931517-A | Polymerization of ethylene | MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) | 1990-06-05 | — | — | US | claimed |
| EP-0303519-A1 | Polymerization of ethylene | MITSUBISHI PETROCHEMICAL CO., LTD. (JP) | 1989-02-15 | — | — | EP | claimed |