Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 12/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817434 | 0.93 | DRD2 (0.51) | MAPTSMN1; SMN2HTR1ADRD2DRD4 | |
| SCHEMBL7826778 | 0.89 | MAPT (0.59) | MAPTSMN1; SMN2HTR1AALDH1A1DRD2 | |
| SCHEMBL7818119 | 0.88 | HTR1A (0.65) | MAPTSMN1; SMN2HTR1A | |
| SCHEMBL7828214 | 0.88 | MAPT (0.70) | MAPTSMN1; SMN2HTR1AALDH1A1POLB | |
| SCHEMBL7817397 | 0.87 | MAPT (0.58) | MAPTSMN1; SMN2HTR1AALDH1A1DRD2 | |
| SCHEMBL7817265 | 0.86 | HTR1A (0.53) | MAPTHTR1AALDH1A1DRD2 | |
| SCHEMBL7817700 | 0.86 | HTR2A (0.56) | MAPTSMN1; SMN2HTR1AALDH1A1 | |
| SCHEMBL7817329 | 0.85 | HTR1A (0.64) | MAPTSMN1; SMN2HTR1AALDH1A1 | |
| SCHEMBL7817707 | 0.85 | MAPT (0.68) | MAPTSMN1; SMN2HTR1AALDH1A1POLB | |
| SCHEMBL7817351 | 0.85 | SMN1; SMN2 (0.57) | MAPTSMN1; SMN2HTR1AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861248-B1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PROD (US) | 2001-12-12 | — | — | EP | claimed |
| EP-0861248-A1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-02 | — | — | EP | claimed |
| US-5750724-A | SEROTONIN 5-HT REUPTAKE INHIBITORS; ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-12 | — | — | US | claimed |
| WO-1997017343-A1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-15 | — | — | WO | claimed |
| EP-0861248-B1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PROD (US) | 2001-12-12 | — | — | EP | disclosed |