Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 7/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817762 | 0.95 | HTR7 (0.39) | MAPTMAPK10MEN1HTTKMT2A | |
| SCHEMBL7818822 | 0.94 | HTR7 (0.42) | MAPTMAPK10MEN1HTTKMT2A | |
| SCHEMBL7817592 | 0.82 | HTR7 (0.43) | HTR7DRD4DRD2DRD1DRD3 | |
| SCHEMBL7820288 | 0.81 | DRD2 (0.40) | HTR7DRD4DRD2DRD3ALDH1A1 | |
| SCHEMBL7977455 | 0.79 | HTR7 (0.40) | MEN1KMT2AHTR7DRD4DRD5 | |
| SCHEMBL7823895 | 0.78 | HTR7 (0.46) | HTR7DRD4DRD2DRD3HTR1A | |
| SCHEMBL7816902 | 0.77 | HTR7 (0.47) | HTR7DRD4DRD2DRD1DRD3 | |
| SCHEMBL7819285 | 0.77 | HTR7 (0.47) | HTR7DRD4DRD3ALDH1A1HTR1A | |
| SCHEMBL7818350 | 0.74 | MAPT (0.41) | MAPTMAPK10MEN1HTTKMT2A | |
| SCHEMBL7808397 | 0.74 | HTR7 (0.39) | MAPTMAPK10MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294677-B1 | HAS SEROTONIN-2-RECEPTER ANTAGONISTIC ACTION AND USEFUL AS A DRUG FOR PREVENTING OR TREATING ISCHEMIC HEART DISEASES, CEREBROVASCULAR DISTURBANCE, AND PERIPHERAL CIRCULATORY DISTURBANCE, WITH MINIMAL TOXIC OR SIDE EFFECTS | SUNTORY LIMITED (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-0749971-B1 | Thiopyran derivatives | SUNTORY LTD (JP) | 2001-03-14 | — | — | EP | disclosed |
| US-6100265-A | BENZOTHIOPYRAN AND THIENOTHIOPYRAN DERIVATIVES; SEROTONIN-2 BLOCKING ACTION; TREATMENT OF CIRCULATORY DISEASES IN GENERAL SUCH AS HYPERTENSION, ISCHEMIC HEART DISEASE, CEREBROVASCULAR DISTURBANCE, AND PERIPHERAL CIRCULATORY DISTURBANCE | SUNTORY LIMITED (JP) | 2000-08-08 | — | — | US | disclosed |
| US-5977111-A | Thiopyran derivatives | SUNTORY LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0749971-A1 | Thiopyran derivatives | SUNTORY LIMITED (JP) | 1996-12-27 | — | — | EP | disclosed |