Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817762 | 0.97 | HTR7 (0.39) | HTR7HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL7817706 | 0.94 | MAPT (0.40) | HTR7HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL7816902 | 0.84 | HTR7 (0.47) | HTR7HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL7820288 | 0.83 | DRD2 (0.40) | HTR7HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL7977455 | 0.81 | HTR7 (0.40) | HTR7HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL7818531 | 0.81 | HTR2C (0.46) | HTR7HTR2ADRD2HTR2CHTR6 | |
| SCHEMBL7823895 | 0.81 | HTR7 (0.46) | HTR7HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL7819285 | 0.79 | HTR7 (0.47) | HTR7HTR1ADRD4HTR2CADRA1A | |
| SCHEMBL7817592 | 0.78 | HTR7 (0.43) | HTR7HTR2ADRD2HTR1ADRD4 | |
| SCHEMBL7808397 | 0.76 | HTR7 (0.39) | HTR7HTR2ADRD2HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294677-B1 | HAS SEROTONIN-2-RECEPTER ANTAGONISTIC ACTION AND USEFUL AS A DRUG FOR PREVENTING OR TREATING ISCHEMIC HEART DISEASES, CEREBROVASCULAR DISTURBANCE, AND PERIPHERAL CIRCULATORY DISTURBANCE, WITH MINIMAL TOXIC OR SIDE EFFECTS | SUNTORY LIMITED (JP) | 2001-09-25 | — | — | US | disclosed |
| EP-0749971-B1 | Thiopyran derivatives | SUNTORY LTD (JP) | 2001-03-14 | — | — | EP | disclosed |
| US-6100265-A | BENZOTHIOPYRAN AND THIENOTHIOPYRAN DERIVATIVES; SEROTONIN-2 BLOCKING ACTION; TREATMENT OF CIRCULATORY DISEASES IN GENERAL SUCH AS HYPERTENSION, ISCHEMIC HEART DISEASE, CEREBROVASCULAR DISTURBANCE, AND PERIPHERAL CIRCULATORY DISTURBANCE | SUNTORY LIMITED (JP) | 2000-08-08 | — | — | US | disclosed |
| US-5977111-A | Thiopyran derivatives | SUNTORY LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0749971-A1 | Thiopyran derivatives | SUNTORY LIMITED (JP) | 1996-12-27 | — | — | EP | disclosed |