Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 4/20 | 0.48 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1880376 | 0.90 | CA12 (0.44) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL5908194 | 0.85 | CA12 (0.52) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL31457896 | 0.84 | CA12 (0.40) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL14275114 | 0.84 | ALDH1A1 (0.42) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL8470255 | 0.83 | NPC1 (0.50) | ALDH1A1CA12CA9CA2RAB9A | |
| SCHEMBL24746387 | 0.82 | ALDH1A1 (0.39) | ALDH1A1HPGDCA12CA9CA2 | |
| SCHEMBL9864401 | 0.81 | NPC1 (0.53) | ALDH1A1CA12CA9CA2RAB9A | |
| SCHEMBL28684383 | 0.81 | NPC1 (0.53) | ALDH1A1CA12CA9CA2RAB9A | |
| SCHEMBL10181457 | 0.81 | NPC1 (0.53) | ALDH1A1CA12CA9CA2RAB9A | |
| SCHEMBL28693146 | 0.81 | NPC1 (0.53) | ALDH1A1CA12CA9CA2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119874601-A | 3, 3-Dimethyl-1, 2,3, 4-tetrahydro-9H-carbazole derivative and preparation method and application thereof | 山东大学 | 2025-04-25 | — | — | CN | claimed |
| CN-114058173-A | Process and composition for producing flexible polyurethane foams | 赢创运营有限公司 | 2022-02-18 | — | — | CN | claimed |
| US-4326076-A | Method for preparing the optically active isomer of 2,2-[[5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-2,3-naphthalene-diyl]bis(oxy)]bis[N,N-dipropylacetamide] | E. R. SQUIBB & SONS, INC. (US) | 1982-04-20 | — | — | US | claimed |
| CN-119874601-A | 3, 3-Dimethyl-1, 2,3, 4-tetrahydro-9H-carbazole derivative and preparation method and application thereof | 山东大学 | 2025-04-25 | — | — | CN | disclosed |
| CN-114058173-A | Process and composition for producing flexible polyurethane foams | 赢创运营有限公司 | 2022-02-18 | — | — | CN | disclosed |
| US-20170143705-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | NOVARTIS AG (CH) | 2017-05-25 | — | — | US | disclosed |
| US-9522149-B2 | Pyrazine derivatives as ENaC blockers | NOVARTIS AG (CH) | 2016-12-20 | — | — | US | disclosed |
| EP-2828261-B1 | Crystalline form of a succinate salt | NOVARTIS AG (CH) | 2016-02-03 | — | — | EP | disclosed |
| US-20150224098-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | NOVARTIS AG (CH) | 2015-08-13 | — | — | US | disclosed |
| US-9050339-B2 | Pyrazine derivatives as ENaC blockers | NOVARTIS AG (CH) | 2015-06-09 | — | — | US | disclosed |
| EP-2616447-B1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | NOVARTIS AG (CH) | 2015-02-18 | — | — | EP | disclosed |
| EP-0328251-A2 | 2-(2-Hydroxy-3-phenoxypropylamino)ethylphenoxyacetamides and processes and intermediates for their preparation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-08-16 | — | — | EP | disclosed |
| EP-0221494-A1 | Process for the preparation of amides of glycolic acid | BAYER AG (DE) | 1987-05-13 | — | — | EP | disclosed |
| EP-0028940-B1 | ANTIARRHYTHMIC TETRAHYDRONAPHTHALENE DERIVATIVES | E.R. Squibb & Sons, Inc. (US) | 1983-09-07 | — | — | EP | disclosed |
| US-4350812-A | Antiarrhythmic tetrahydronaphthalene derivatives | E. R. SQUIBB & SONS, INC. (US) | 1982-09-21 | — | — | US | disclosed |
| US-4302453-A | Antiarrhythmic tetrahydronaphthalene derivatives | E. R. SQUIBB & SONS, INC. (US) | 1981-11-24 | — | — | US | disclosed |
| US-4279902-A | Anti-arrhythmia agents | E. R. SQUIBB & SONS, INC. (US) | 1981-07-21 | — | — | US | disclosed |
| EP-0028940-A1 | Antiarrhythmic tetrahydronaphthalene derivatives | E.R. Squibb & Sons, Inc. (US) | 1981-05-20 | — | — | EP | disclosed |
| US-4252801-A | ANTIARRHYTHMIA AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1981-02-24 | — | — | US | disclosed |
| US-4099954-A | Amide phosphorothiolate herbicides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1978-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150224098-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | REN, SCNN1B, SCN5A | ALDH1A1 2428/4885HPGD 2231/4885CA12 4017/4885 |
| US-20170143705-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | REN, SCNN1B, SCN5A | ALDH1A1 2428/4885HPGD 2231/4885CA12 4017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.